Bloody Long Walk Melbourne 2017

Last Sunday, we walked the annual Bloody Long Walk to raise awareness and money for mitochondrial disease. The 35km walk through picturesque Melbourne along the Yarra River was a great experience and the beautiful spring day allowed us to recover our sore feet in the cold waters of St Kilda Beach.

See below some images from the awesome walk:

Complex I assembly - it's complicated...

In our latest review, Luke Formosa, Marris Dibley, David Stroud and Mike Ryan outline the current understanding of mitochondrial complex I assembly, focussing on the role and importance of complex I assembly factors during this process.

Abstract: 

Mitochondrial complex I is the primary entry point for electrons into the electron transport chain, required for the bulk of cellular ATP production via oxidative phosphorylation. Complex I consists of 45 subunits, which are encoded by both nuclear and mitochondrial DNA. Currently, at least 15 assembly factors are known to be required for the complete maturation of complex I. Mutations in the genes encoding subunits and assembly factors leads to complex I deficiency, which can manifest as mitochondrial disease. The current model of complex I assembly suggests that the enzyme is built by the association of a set of smaller intermediate modules containing specific conserved core subunits and additional accessory subunits. Each module must converge in a spatially and temporally orchestrated fashion to allow assembly of the mature holoenzyme to occur. This review outlines the current understanding of complex I biogenesis, with an emphasis on the assembly factors that facilitate the building of this architectural giant.

Please click here to see the publication.

New research paper published - novel genetic analysis approach for Leigh Syndrome

Dr David Stroud, a NHMRC Doherty Fellow from our lab, co-lead a study with collaborators from the Murdoch Children’s Research Institute, investigating the genetic underpinnings and proteomic changes of patients with Leigh Syndrome.  

Their research revealed that mutations in the MRPS34 gene, a component of the mitoribosome, leading to severe effects on the protein synthesis of mitochondrial encoded proteins required for mitochondrial respiration and energy production. 

A link to the news post on the BDI homepage can be found here.

The publication in the American Journal of Human Genetics can be found here.

Lab Hike 2017: Razorback Trail, Cathedral Ranges National Park

With some delay (due to the navigation capabilities of one senior PhD student), the Ryan lab members started their annual walk in the late morning from the Cooks Mill Ground up to the Razorback Tail.

After a steep and demanding walk up to the sattle of the mountain ranges, we could enjoy a lunch break with a fantastic view over the Cathedral Ranges.

After lunch, we continued climbing on the back of the Razorback, heading towards the Sugarloaf Peak. Reaching the peak, we turned around and could enjoy a fantastic sunset illuminating the mountain ranges in warm light.

A brief Schnitzel and Parma stop was the adequate pit stop for all of us before we got back into the cars and headed home.