2018

Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission. Sukrut C. Kamerkar, Felix Kraus, Alice J. Sharpe, Thomas J. Pucadyil & Michael T. Ryan. Nature Communications Volume 9, Article number: 5239 (2018) Article

VDAC2 enables BAX to mediate apoptosis and limit tumor development. Hui San Chin, Mark X. Li, Iris K. L. Tan, Robert L. Ninnis, Boris Reljic, Kristen Scicluna, Laura F. Dagley, Jarrod J. Sandow, Gemma L. Kelly, Andre L. Samson, Stephane Chappaz, Seong L. Khaw, Catherine Chang, Andrew Morokoff, Kerstin Brinkmann, Andrew Webb, Colin Hockings, Cathrine M. Hall, Andrew J. Kueh, Michael T. Ryan, Ruth M. Kluck, Philippe Bouillet, Marco J. Herold, Daniel H. D. Gray, David C. S. Huang, Mark F. van Delft & Grant Dewson. Nature Communications Volume 9, Article number: 4976 (2018) Text

OXA1L mutations cause mitochondrial encephalopathy and a combined oxidative phosphorylation defect. Thompson K, Mai N, Oláhová M, Scialó F, Formosa LE, Stroud DA, Garrett M, Lax NZ, Robertson FM, Jou C, Nascimento A, Ortez C, Jimenez-Mallebrera C, Hardy SA, He L, Brown GK, Marttinen P, McFarland R, Sanz A, Battersby BJ, Bonnen PE, Ryan MT, Chrzanowska-Lightowlers ZM, Lightowlers RN, Taylor RW. EMBO Mol Med. 2018 Nov;10(11). pii: e9060. doi: 10.15252/emmm.201809060. Pubmed

Bi-allelic Mutations in NDUFA6 Establish Its Role in Early-Onset Isolated Mitochondrial Complex I Deficiency. Alston CL, Heidler J, Dibley MG, Kremer LS, Taylor LS, Fratter C, French CE, Glasgow RIC, Feichtinger RG, Delon I, Pagnamenta AT, Dolling H, Lemonde H, Aiton N, Bjørnstad A, Henneke L, Gärtner J, Thiele H, Tauchmannova K, Quaghebeur G, Houstek J, Sperl W, Raymond FL, Prokisch H, Mayr JA, McFarland R, Poulton J, Ryan MT, Wittig I, Henneke M, Taylor RW. Am J Hum Genet. 2018 Oct 4;103(4):592-601. doi: 10.1016/j.ajhg.2018.08.013. Epub 2018 Sep 20. Pubmed

Mitochondrial OXPHOS complex assembly lines. Luke E. Formosa, Michael T. Ryan. Nat Cell Biol. 2018 Apr 16. doi: 10.1038/s41556-018-0098-z. Pubmed

Mitochondrial fission protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells. Hoque A, Sivakumaran P, Bond ST, Ling NXY, Kong AM, Scott JW, Bandara N, Hernández D, Liu GS, Wong RCB, Ryan MT, Hausenloy DJ, Kemp BE, Oakhill JS, Drew BG, Pébay A, Lim SY. Cell Death Discov. 2018 Mar 5;4:39. doi: 10.1038/s41420-018-0042-9. eCollection 2018 Dec. Pubmed

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis. McArthur K, Whitehead LW, Heddleston JM, Li L, Padman BS, Oorschot V, Geoghegan ND, Chappaz S, Davidson S, San Chin H, Lane RM, Dramicanin M Saunders TL, Sugiana C, Lessene R, Osellame LD, Chew TL, Dewson G, Lazarou M, Ramm G, Lessene G, Ryan MT, Rogers KL, van Delft MF, Kile BT. Science. 2018 Feb 23. doi: 10.1126/science.aao6047. Pubmed

Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposityand improves insulin sensitivity in mice. Wali JA, Galic S, Tan CY, Gurzov EN, Frazier AE, Connor T, Ge J, Pappas EG, Stroud D, Varanasi LC, Selck C, Ryan MT, Thorburn DR, Kemp BE, Krishnamurthy B, Kay TW, McGee SL, Thomas HE. Cell Death Differ. 2018 Jan;25(1):217-225. doi: 10.1038/cdd.2017.168 Pubmed


2017

Mitochondria - the energy powerhouses. Ryan MT. Semin Cell Dev Biol. 2017 doi: 10.1016/j.semcdb.2017.09.038 Pubmed

Identification of new channels by systematic analysis of the mitochondrial outer membrane. Krüger V, Becker T, Becker L, Montilla-Martinez M, Ellenrieder L, Vögtle FN, Meyer HE, Ryan MT, Wiedemann N, Warscheid B, Pfanner N, Wagner R, Meisinger C. J Cell Biol. 2017 Nov 6. doi: 10.1083/jcb.201706043  Pubmed

The constriction and scission machineries involved in mitochondrial fission. Felix Kraus, Michael T. Ryan. J Cell Sci 2017 doi: 10.1242/jcs.199562 Pubmed

Sengers Syndrome-Associated Mitochondrial Acylglycerol Kinase Is a Subunit of the HumanTIM22 Protein Import Complex. Kang Y, Stroud DA, Baker MJ, De Souza DP, Frazier AE, Liem M, Tull D, Mathivanan S, McConville MJ, Thorburn DR, Ryan MT, Stojanovski D. Mol Cell. 2017 Aug 3. doi: 10.1016/j.molcel.2017.06.014 Pubmed

Building a complex complex: assembly of mitochondrial respiratory chain complex I. Luke E. Formosa, Marris G. Dibley, David A. Stroud, Michael T. Ryan. Semin Cell Dev Biol. 2017 Aug 1. doi.org/10.1016/j.semcdb.2017.08.011 Pubmed

Preservation of skeletal muscle mitochondrial content in older adults: relationship between mitochondria, fibre type and high-intensity exercise training. Victoria L. Wyckelsma, Itamar Levinger,  Michael J. McKenna, Luke E. Formosa, Michael T. Ryan, Aron C. Petersen, Mitchell J. Anderson, Robyn M. Murphy. J Physiol. 2017 Mar 1. doi: 10.1113/JP273950 Pubmed


2016

A novel isoform of the human mitochondrial complex I subunit NDUFV3. Marris G. Dibley, Michael T. Ryan, David A. Stroud, FEBS Lett. 2016 Dec 17. doi: 10.1002/1873-3468.12527 Pubmed

Mitochondrial fusion: Reaching the end of mitofusin's tether. Luke E. Formosa, Michael T. Ryan. J.  Cell Biol. 2016 Nov 23. pii: jcb.201611048. Pubmed

Accessory subunits are integral for assembly and function of human mitochondrial complex I. David A. Stroud,  Elliot E. Surgenor,  Luke E. Formosa,  Boris Reljic,  Ann E. Frazier,  Marris G. Dibley,  Laura D. Osellame,  Tegan Stait,  Traude H. Beilharz,  David R. Thorburn,  Agus Salim &  Michael T. Ryan  Nature (14 September 2016) | doi:10.1038/nature19754 Pubmed http://rdcu.be/kkQg

Biallelic Mutations in TMEM126B Cause Severe Complex I Deficiency with a Variable Clinical Phenotype. Charlotte AL, Alison CG, Luke FE,  Strecker V, Oláhová M, Haack TB, Smet J, Stouffs K, Diakumis P, Ciara E, Cassiman D, Romain N, Yarham JW, He L, De Paepe B, Vanlander AV, Seneca S, Feichtinger RG, Płoski R, Rokicki D, Pronicka E, Haller RG, Van Hove JLK, Bahlo M, Mayr JA, Van Coster R, Prokisch H, Wittig I, Ryan MT, Thorburn DR, Taylor RW. The American Journal of Human Genetics, 99, 2016 June, DOI: http://dx.doi.org/10.1016/j.ajhg.2016.05.021 Pubmed

A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes. PeirisH, DuffieldMD, FadistaJ, JessupCF, KashmirV, GendersAJ, McGeeSL, MartinAM, SaiediM, MortonN, CarterR, CousinMA, KokotosAC, OskolkovN, VolkovP, HoughTA, FisherEM, TybulewiczVL, BusciglioJ, CoskunPE, BeckerA, BelichenkoPV, MobleyWC, Ryan MT, Chan JY, LaybuttDR, CoatesPT, YangS, LingC, GroopL, PritchardMA, KeatingDJ. PLoS Genet. 2016 May 19;12(5):e1006033. doi: 10.1371/journal.pgen.1006033. Pubmed

Cooperative and independent roles of Drp1 adaptors Mff and MiD49/51 in mitochondrial fission. Osellame LD, Singh AP, Stroud DA, Palmer CS, Stojanovski D, Ramachandran R, Ryan MT. J Cell Sci. 2016 Apr 12. pii: jcs.185165.  Pubmed

Deficiency in apoptosis inducing factor recapitulates chronic kidney disease via aberrant mitochondrial homeostasis.
Coughlan MT, Higgins GC, Nguyen TV, Penfold SA, Thallas-Bonke V, Tan SM, Ramm G, Van Bergen NJ, Henstridge DC, Sourris KC, Harcourt BE, Trounce IA, Robb PM, Laskowski A, McGee SL, Genders AJ, Walder K, Drew BG, Gregorevic P, Qian H, Thomas MC, Jerums G, Macisaac RJ, Skene A, Power DA, Ekinci EI, Wijeyeratne XW, Gallo LA, Herman-Edelstein M, Ryan MT, Cooper ME, Thorburn DR, Forbes JM.
Diabetes. 2016 Jan 28. pii: db150864. Pubmed

Translation and Assembly of Radiolabeled Mitochondrial DNA-Encoded Protein Subunits from Cultured Cells and Isolated Mitochondria. Formosa LE, Hofer A, Tischner C, Wenz T, Ryan MT. Methods Mol Biol. 2016;1351:115-29. doi: 10.1007/978-1-4939-3040-1_9. Pubmed

 


 

2015

COA6 is a mitochondrial complex IV assembly factor critical for biogenesis of mtDNA-encoded COX2. Stroud DA, Maher MJ, Lindau C, Vögtle FN, Frazier AE, Surgenor E, Mountford H, Singh AP, Bonas M, Oeljeklaus S, Warscheid B, Meisinger C, Thorburn DR, Ryan MT. Hum Mol Genet. 2015 Oct 1;24(19):5404-15. Pubmed

Analysis of ER-mitochondria contacts using correlative fluorescence microscopy and soft X-ray tomography of mammalian cells. Elgass KD, Smith EA, LeGros MA, Larabell CA, Ryan MT. J Cell Sci. 2015 Aug 1;128(15):2795-804. Pubmed

Splitting up the powerhouse: structural insights into the mechanism of mitochondrial fission.
Richter V, Singh AP, Kvansakul M, Ryan MT, Osellame LD. Cell Mol Life Sci. 2015 Oct;72(19):3695-707. Pubmed

FunRich: An open access standalone functional enrichment and interaction network analysis tool. Pathan M, Keerthikumar S, Ang CS, Gangoda L, Quek CY, Williamson NA, Mouradov D, Sieber OM, Simpson RJ, Salim A, Bacic A, Hill AF, Stroud DA, Ryan MT, Agbinya JI, Mariadason JM, Burgess AW, Mathivanan S. Proteomics. 2015 Aug;15(15):2597-601. Pubmed

Characterization of mitochondrial FOXRED1 in the assembly of respiratory chain complex I.
Formosa LE, Mimaki M, Frazier AE, McKenzie M, Stait TL, Thorburn DR, Stroud DA, Ryan MT. Hum Mol Genet. 2015 May 15;24(10):2952-65. Pubmed


2014

Mapping biological composition through quantitative phase and absorption X-ray ptychography. Jones MW, Elgass K, Junker MD, Luu MB, Ryan MT, Peele AG, van Riessen GA. Sci Rep. 2014 Oct 28;4:6796. Pubmed

Neuronal and astrocyte dysfunction diverges from embryonic fibroblasts in the Ndufs4fky/fky mouse. Bird MJ, Wijeyeratne XW, Komen JC, Laskowski A, Ryan MT, Thorburn DR, Frazier AE. Biosci Rep. 2014 Nov 21;34(6):e00151. Pubmed

Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function. Ma SB, Nguyen TN, Tan I, Ninnis R, Iyer S, Stroud DA, Menard M, Kluck RM, Ryan MT, Dewson G. Cell Death Differ. 2014 Dec;21(12):1925-35. Pubmed

Stalking the mitochondrial ATP synthase: Ina found guilty by association. Stroud DA, Ryan MT. EMBO J. 2014 Aug 1;33(15):1617-8 Pubmed

Structural and functional analysis of MiD51, a dynamin receptor required for mitochondrial fission. Richter V, Palmer CS, Osellame LD, Singh AP, Elgass K, Stroud DA, Sesaki H, Kvansakul M, Ryan MT. J Cell Biol. 2014 Feb 17;204(4):477-86 Pubmed

A founder mutation in PET100 causes isolated complex IV deficiency in Lebanese individuals with Leigh syndrome. Lim SC, Smith KR, Stroud DA, Compton AG, Tucker EJ, Dasvarma A, Gandolfo LC, Marum JE, McKenzie M, Peters HL, Mowat D, Procopis PG, Wilcken B, Christodoulou J, Brown GK, Ryan MT, Bahlo M, Thorburn DR. Am J Hum Genet. 2014 Feb 6;94(2):209-22.

 

More publications...